African American and European American Therapists’ Experiences of Addressing Race in Cross-Racial Psychotherapy Dyads

Using Consensual Qualitative Research, 12 licensed psychologists’ overall experiences addressing race in psychotherapy were investigated, as were their experiences addressing race in a specific cross-racial therapy dyad. Results indicated that only African American psychologists reported routinely addressing race with clients of color or when race was part of a client’s presenting concern. European American psychologists indicated that they would address race if clients raised the topic, and some reported that they did not normally address race with racially different clients. When discussing a specific cross-racial dyad, African American therapists more often than European American therapists addressed race because they perceived client discomfort. Only European American therapists reported feeling uncomfortable addressing race, but therapists of both races perceived that such discussions had positive effects

Combined Effects of Montmorillonite Clay, Carbon Nanofiber, and Fire Retardant on Mechanical and Flammability Properties of Polyamide 11 Nanocomposites

This paper is focused on the development of polyamide 11 (PA11) nanocomposites with enhanced fire retardant (FR) properties for application in selective laser sintering (SLS). Test specimens of PA11 containing various percentages of intumescent FR additive, montmorillonite (MMT) clay, and carbon nanofiber (CNF) were prepared via the twin screw extrusion technique. The combined effects of MMT clay, CNF, FR additives on the mechanical and flammability properties of these PA11 nanocomposites are studied. Izod impact testing, tensile testing, and SEM analysis of are used to characterize mechanical properties. UL-94 and SEM analysis of char surfaces are used to characterize the flammability properties of these materials. Results are analyzed to determine any synergistic effects among the additives to the material properties of PA11.Mechanical Engineerin

The eICU Collaborative Research Database, a freely available multi-center database for critical care research

Critical care patients are monitored closely through the course of their illness. As a result of this monitoring, large amounts of data are routinely collected for these patients. Philips Healthcare has developed a telehealth system, the eICU Program, which leverages these data to support management of critically ill patients. Here we describe the eICU Collaborative Research Database, a multi-center intensive care unit (ICU)database with high granularity data for over 200,000 admissions to ICUs monitored by eICU Programs across the United States. The database is deidentified, and includes vital sign measurements, care plan documentation, severity of illness measures, diagnosis information, treatment information, and more. Data are publicly available after registration, including completion of a training course in research with human subjects and signing of a data use agreement mandating responsible handling of the data and adhering to the principle of collaborative research. The freely available nature of the data will support a number of applications including the development of machine learning algorithms, decision support tools, and clinical research

Preclinical Analysis of JAA-F11, a Specific Anti-Thomsen-Friedenreich Antibody via Immunohistochemistry and In Vivo Imaging.

The tumor specificity of JAA-F11, a novel monoclonal antibody specific for the Thomsen-Friedenreich cancer antigen (TF-Ag-alpha linked), has been comprehensively studied by in vitro immunohistochemical (IHC) staining of human tumor and normal tissue microarrays and in vivo biodistribution and imaging by micro-positron emission tomography imaging in breast and lung tumor models in mice. The IHC analysis detailed herein is the comprehensive biological analysis of the tumor specificity of JAA-F11 antibody performed as JAA-F11 is progressing towards preclinical safety testing and clinical trials. Wide tumor reactivity of JAA-F11, relative to the matched mouse IgG3 (control), was observed in 85% of 1269 cases of breast, lung, prostate, colon, bladder, and ovarian cancer. Staining on tissues from breast cancer cases was similar regardless of hormonal or Her2 status, and this is particularly important in finding a target on the currently untargetable triple-negative breast cancer subtype. Humanization of JAA-F11 was recently carried out as explained in a companion paper "Humanization of JAA-F11, a Highly Specific Anti-Thomsen-Friedenreich Pancarcinoma Antibody and In Vitro Efficacy Analysis" (Neoplasia 19: 716-733, 2017), and it was confirmed that humanization did not affect chemical specificity. IHC studies with humanized JAA-F11 showed similar binding to human breast tumor tissues. In vivo imaging and biodistribution studies in a mouse syngeneic breast cancer model and in a mouse-human xenograft lung cancer model with humanized 124I- JAA-F11 construct confirmed in vitro tumor reactivity and specificity. In conclusion, the tumor reactivity of JAA-F11 supports the continued development of JAA-F11 as a targeted cancer therapeutic for multiple cancers, including those with unmet need

Questions, conjectures, and data about multiplicity lists for trees

We review and discuss a number of questions and conjectures about multiplicity lists occurring among real symmetric matrices whose graph is a tree. Our investigation is aided by a new electronic database containing all multiplicity lists for trees on fewer than 12 vertices. Some questions and conjectures are familiar and some are new, and new information is given about several. (C) 2016 Elsevier Inc. All rights reserved